With VirtualBox 4.3, it is possible to install the oldest known pre-release of Windows NT directly from CD, the way Microsoft intended. This is the Fall ’91 Comdex preview which only supported the x86 architecture and a very short list of hardware devices. The pre-release was available only on CD-ROM and although it was possible to install it more or less manually from DOS, there was a graphical installer on the CD-ROM.
However, the hardware support being as limited as it was, the only supported storage controller was Adaptec AHA-1540 or compatible with a SCSI CD-ROM attached. Fortunately this is adequately emulated by the BusLogic SCSI HBA device in VirtualBox.